Integrins in Health and Disease

Integrins in Health and Disease

Integrins in Health and Disease provides a detailed exploration of integrins as central players in cell matrix interactions and cell cell interactions. These heterodimeric receptors connect cells with the extracellular matrix proteins and influence processes such as tissue morphogenesis, wound healing, and cell growth regulation. Beyond physiology, the book also discusses their roles in conditions like autoimmunity, infectious disease, and carcinogenesis.

The content explains the function of collagen binding integrins, laminin binding integrins, and nephronectin binding integrins, supported by findings from knockout models and animal models. Special focus is given to pathological tissue remodeling in joints and cardiac tissue, along with how integrins contribute to tumor fibrosis, angiogenesis, and tumor progression.

Further sections cover their importance in the immune system, the targeting of integrin ligand interactions with antibodies, and their role as receptors in bacterial invasion and viral invasion. As part of the Biology of Extracellular Matrix series, published with the American Society for Matrix Biology and the International Society for Matrix Biology, this book is a valuable reference for researchers, clinicians, and students studying cell adhesion molecules and the extracellular matrix.

Key Benefits

• Explains integrin roles in health and disease across physiological and pathological processes
• Covers structural and functional insights into extracellular matrix and cell adhesion molecules
• Includes data from animal models and knockout models for research applications
• Highlights clinical relevance in autoimmunity, infectious disease, and carcinogenesis
• Discusses mechanisms of tumor fibrosis, angiogenesis, and tumor progression
• Reviews therapeutic strategies targeting integrin ligand interactions with antibodies

Price in Pakistan

The black and white edition of this title is available at PKR 850, while the matt paper edition is priced at PKR 1800. Prices may vary slightly depending on the platform or bookstore.

Availability

This book can be ordered through Books N Beyond Medical Books Shop with convenient options for home delivery and cash on delivery throughout Pakistan. The shop also offers a wide range of medical books for researchers, medical students, and professionals.